Enzymes
| UniProtKB help_outline | 1,312 proteins |
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- Name help_outline 1D-chiro-inositol Identifier CHEBI:27372 (CAS: 643-12-9) help_outline Charge 0 Formula C6H12O6 InChIKeyhelp_outline CDAISMWEOUEBRE-LKPKBOIGSA-N SMILEShelp_outline O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline Na+ Identifier CHEBI:29101 (CAS: 17341-25-2) help_outline Charge 1 Formula Na InChIKeyhelp_outline FKNQFGJONOIPTF-UHFFFAOYSA-N SMILEShelp_outline [Na+] 2D coordinates Mol file for the small molecule Search links Involved in 259 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:73315 | RHEA:73316 | RHEA:73317 | RHEA:73318 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells.
Lin X., Ma L., Fitzgerald R.L., Ostlund R.E. Jr.
To characterize the function of the sodium/inositol symporter SMIT2 in skeletal muscle, human SMIT2 cDNA was transfected into L6 myoblasts using pcDNA3.1 expression vector. Compared with the pcDNA3.1 vector only transfection, this overexpression increased the uptake of [(3)H]D-chiro-inositol (DCI) ... >> More
To characterize the function of the sodium/inositol symporter SMIT2 in skeletal muscle, human SMIT2 cDNA was transfected into L6 myoblasts using pcDNA3.1 expression vector. Compared with the pcDNA3.1 vector only transfection, this overexpression increased the uptake of [(3)H]D-chiro-inositol (DCI) by 159-fold. [(3)H]myo-Inositol uptake increased by 37-fold. In contrast, [(14)C]D-glucose, [(14)C]2-deoxy-D-glucose, or [(14)C]3-O-methyl-D-glucose uptake remained unchanged in the presence of either 0, 5.5, or 25 mM unlabeled glucose. The K(m) of DCI and myo-inositol for DCI uptake was 111.0 and 158.0 microM, respectively, whereas glucose competed for DCI uptake with a K(i) of 6.1 mM. Insulin treatment of non-transfected L6 cells (2 microM for 24 h) increased [(3)H]DCI specific uptake 18-fold. DCI transport is up regulated by insulin and competitively inhibited by millimolar levels of glucose. Therefore, expression and/or function of SMIT2, a high affinity transporter specific for DCI and myo-inositol, may be reduced in diabetes mellitus, insulin resistance and polycystic ovary syndrome causing the abnormal DCI metabolism observed in these conditions. << Less
Arch. Biochem. Biophys. 481:197-201(2009) [PubMed] [EuropePMC]