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- Name help_outline (2E,6E,10E)-geranylgeranyl diphosphate Identifier CHEBI:58756 (Beilstein: 3574726) help_outline Charge -3 Formula C20H33O7P2 InChIKeyhelp_outline OINNEUNVOZHBOX-QIRCYJPOSA-K SMILEShelp_outline CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 63 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline talarodiene Identifier CHEBI:193158 Charge 0 Formula C20H32 InChIKeyhelp_outline XTOGEKDHHWZDDZ-JAMRKFNNSA-N SMILEShelp_outline [H][C@@]12C[C@@]3(C)CCC(C)(C)C=C3C\C=C(C)/[C@]1([H])CC[C@@H]2C 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline diphosphate Identifier CHEBI:33019 (Beilstein: 185088) help_outline Charge -3 Formula HO7P2 InChIKeyhelp_outline XPPKVPWEQAFLFU-UHFFFAOYSA-K SMILEShelp_outline OP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1,188 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:74547 | RHEA:74548 | RHEA:74549 | RHEA:74550 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Identification and characterization of a cryptic bifunctional type I diterpene synthase involved in talaronoid biosynthesis from a marine-derived fungus.
Zhang P., Wu G., Heard S.C., Niu C., Bell S.A., Li F., Ye Y., Zhang Y., Winter J.M.
We report the identification of the <i>tnd</i> biosynthetic cluster from the marine-derived fungus <i>Aspergillus flavipes</i> and the in vivo characterization of a cryptic type I diterpene synthase. The heterologous expression of the bifunctional terpene synthase led to the discovery of a diterpe ... >> More
We report the identification of the <i>tnd</i> biosynthetic cluster from the marine-derived fungus <i>Aspergillus flavipes</i> and the in vivo characterization of a cryptic type I diterpene synthase. The heterologous expression of the bifunctional terpene synthase led to the discovery of a diterpene backbone, talarodiene, harboring a benzo[<i>a</i>]cyclopenta[<i>d</i>]cyclooctane tricyclic fused ring system. The conversion of geranylgeranyl diphosphate to talarodiene was investigated using <sup>13</sup>C-labeling studies, and stable isotope tracer experiments showed the biotransformation of talarodiene into talaronoid C. << Less