Reaction participants Show >> << Hide
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Namehelp_outline
N-terminal Nα-acetyl-L-cysteinyl-L-glutamyl-[protein]
Identifier
RHEA-COMP:18396
Reactive part
help_outline
- Name help_outline Nα-acetyl-L-cysteinyl-L-glutamyl residue Identifier CHEBI:193601 Charge -1 Formula C10H14N2O5S SMILEShelp_outline N([C@H](C(=O)*)CCC([O-])=O)C(=O)[C@@H](NC(=O)C)CS 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,485 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
N-terminal L-glutamyl-[protein]
Identifier
RHEA-COMP:12668
Reactive part
help_outline
- Name help_outline L-glutamyl group Identifier CHEBI:64721 Charge 0 Formula C5H8NO3 SMILEShelp_outline C(*)(=O)[C@@H]([NH3+])CCC(=O)[O-] 2D coordinates Mol file for the small molecule Search links Involved in 4 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline N-acetyl-L-cysteine Identifier CHEBI:78236 Charge -1 Formula C5H8NO3S InChIKeyhelp_outline PWKSKIMOESPYIA-BYPYZUCNSA-M SMILEShelp_outline CC(=O)N[C@@H](CS)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 9 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:74583 | RHEA:74584 | RHEA:74585 | RHEA:74586 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Actin maturation requires the ACTMAP/C19orf54 protease.
Haahr P., Galli R.A., van den Hengel L.G., Bleijerveld O.B., Kazokaite-Adomaitiene J., Song J.Y., Kroese L.J., Krimpenfort P., Baltissen M.P., Vermeulen M., Ottenheijm C.A.C., Brummelkamp T.R.
Protein synthesis generally starts with a methionine that is removed during translation. However, cytoplasmic actin defies this rule because its synthesis involves noncanonical excision of the acetylated methionine by an unidentified enzyme after translation. Here, we identified C19orf54, named AC ... >> More
Protein synthesis generally starts with a methionine that is removed during translation. However, cytoplasmic actin defies this rule because its synthesis involves noncanonical excision of the acetylated methionine by an unidentified enzyme after translation. Here, we identified C19orf54, named ACTMAP (actin maturation protease), as this enzyme. Its ablation resulted in viable mice in which the cytoskeleton was composed of immature actin molecules across all tissues. However, in skeletal muscle, the lengths of sarcomeric actin filaments were shorter, muscle function was decreased, and centralized nuclei, a common hallmark of myopathies, progressively accumulated. Thus, ACTMAP encodes the missing factor required for the synthesis of mature actin and regulates specific actin-dependent traits in vivo. << Less
Science 377:1533-1537(2022) [PubMed] [EuropePMC]
This publication is cited by 3 other entries.