Reaction participants Show >> << Hide
- Name help_outline 3',5'-cyclic AMP Identifier CHEBI:58165 Charge -1 Formula C10H11N5O6P InChIKeyhelp_outline IVOMOUWHDPKRLL-KQYNXXCUSA-M SMILEShelp_outline Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 6 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:76223 | RHEA:76224 | RHEA:76225 | RHEA:76226 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Isolation of a family of organic anion transporters from human liver and kidney.
Sun W., Wu R.R., van Poelje P.D., Erion M.D.
Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells show ... >> More
Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha-ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters. << Less
Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.