Reaction participants Show >> << Hide
- Name help_outline N-acetyl-β-D-glucosaminyl-(1→4)-1,6-anhydro-N-acetyl-β-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine Identifier CHEBI:195208 Charge -2 Formula C37H57N7O20 InChIKeyhelp_outline UPFMKPIBAIPLHT-RSJSDIDPSA-L SMILEShelp_outline O1C[C@@H]2[C@H]([C@@H]([C@H]([C@H]1O2)NC(C)=O)O[C@@H](C(N[C@H](C(N[C@H](CCC(N[C@@H](CCC[C@H](C(=O)[O-])[NH3+])C(N[C@@H](C([O-])=O)C)=O)=O)C(=O)[O-])=O)C)=O)C)O[C@]3([C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(=O)C)[H] 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,932 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:76355 | RHEA:76356 | RHEA:76357 | RHEA:76358 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Substrate specificity of the AmpG permease required for recycling of cell wall anhydro-muropeptides.
Cheng Q., Park J.T.
AmpG was originally identified as a gene required for induction of beta-lactamase. Subsequently, we found AmpG to be a permease required for recycling of murein tripeptide and uptake of anhydro-muropeptides. We have now studied the specificity of the AmpG permease. The principal requirement is for ... >> More
AmpG was originally identified as a gene required for induction of beta-lactamase. Subsequently, we found AmpG to be a permease required for recycling of murein tripeptide and uptake of anhydro-muropeptides. We have now studied the specificity of the AmpG permease. The principal requirement is for the presence of the disaccharide, N-acetylglucosaminyl-beta-1,4-anhydro-N-acetylmuramic acid (GlcNAc-anhMurNAc). These unique substrates for AmpG, which contain murein peptides linked to GlcNAc-anhMurNAc, are produced by turnover of the cell wall during logarithmic growth. AmpG permease is sensitive to carbonylcyanide m-chlorophenylhydrazone, demonstrating that AmpG permease is a single-component permease and that transport is dependent on the proton motive force. << Less
J. Bacteriol. 184:6434-6436(2002) [PubMed] [EuropePMC]
This publication is cited by 3 other entries.
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SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans.
Paik D., Monahan A., Caffrey D.R., Elling R., Goldman W.E., Silverman N.
Tracheal cytotoxin (TCT), a monomer of DAP-type peptidoglycan from <i>Bordetella pertussis</i>, causes cytopathology in the respiratory epithelia of mammals and robustly triggers the <i>Drosophila</i> Imd pathway. PGRP-LE, a cytosolic innate immune sensor in <i>Drosophila</i>, directly recognizes ... >> More
Tracheal cytotoxin (TCT), a monomer of DAP-type peptidoglycan from <i>Bordetella pertussis</i>, causes cytopathology in the respiratory epithelia of mammals and robustly triggers the <i>Drosophila</i> Imd pathway. PGRP-LE, a cytosolic innate immune sensor in <i>Drosophila</i>, directly recognizes TCT and triggers the Imd pathway, yet the mechanisms by which TCT accesses the cytosol are poorly understood. In this study, we report that CG8046, a <i>Drosophila</i> SLC46 family transporter, is a novel transporter facilitating cytosolic recognition of TCT, and plays a crucial role in protecting flies against systemic <i>Escherichia coli</i> infection. In addition, mammalian SLC46A2s promote TCT-triggered NOD1 activation in human epithelial cell lines, indicating that SLC46As is a conserved group of peptidoglycan transporter contributing to cytosolic immune recognition. << Less
J. Immunol. 199:263-270(2017) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.