Reaction participants Show >> << Hide
- Name help_outline a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine Identifier CHEBI:36702 Charge 0 Formula C9H18NO7PR2 SMILEShelp_outline C[N+](C)(C)CCOP([O-])(=O)OC[C@@H](CO[*])OC([*])=O 2D coordinates Mol file for the small molecule Search links Involved in 41 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline a 1,2-diacylglycerol Identifier CHEBI:49172 Charge 0 Formula C5H6O5R2 SMILEShelp_outline OCC(COC([*])=O)OC([*])=O 2D coordinates Mol file for the small molecule Search links Involved in 296 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline a 1-O-alkyl-sn-glycero-3-phosphocholine Identifier CHEBI:30909 Charge 0 Formula C8H19NO6PR SMILEShelp_outline C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO[*] 2D coordinates Mol file for the small molecule Search links Involved in 42 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline a triacylglycerol Identifier CHEBI:17855 Charge 0 Formula C6H5O6R3 SMILEShelp_outline [*]C(=O)OCC(COC([*])=O)OC([*])=O 2D coordinates Mol file for the small molecule Search links Involved in 131 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:77759 | RHEA:77760 | RHEA:77761 | RHEA:77762 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
|
Publications
-
Identification of an alternative triglyceride biosynthesis pathway.
McLelland G.L., Lopez-Osias M., Verzijl C.R.C., Ellenbroek B.D., Oliveira R.A., Boon N.J., Dekker M., van den Hengel L.G., Ali R., Janssen H., Song J.Y., Krimpenfort P., van Zutphen T., Jonker J.W., Brummelkamp T.R.
Triacylglycerols (TAGs) are the main source of stored energy in the body, providing an important substrate pool for mitochondrial beta-oxidation. Imbalances in the amount of TAGs are associated with obesity, cardiac disease and various other pathologies<sup>1,2</sup>. In humans, TAGs are synthesiz ... >> More
Triacylglycerols (TAGs) are the main source of stored energy in the body, providing an important substrate pool for mitochondrial beta-oxidation. Imbalances in the amount of TAGs are associated with obesity, cardiac disease and various other pathologies<sup>1,2</sup>. In humans, TAGs are synthesized from excess, coenzyme A-conjugated fatty acids by diacylglycerol O-acyltransferases (DGAT1 and DGAT2)<sup>3</sup>. In other organisms, this activity is complemented by additional enzymes<sup>4</sup>, but whether such alternative pathways exist in humans remains unknown. Here we disrupt the DGAT pathway in haploid human cells and use iterative genetics to reveal an unrelated TAG-synthesizing system composed of a protein we called DIESL (also known as TMEM68, an acyltransferase of previously unknown function) and its regulator TMX1. Mechanistically, TMX1 binds to and controls DIESL at the endoplasmic reticulum, and loss of TMX1 leads to the unconstrained formation of DIESL-dependent lipid droplets. DIESL is an autonomous TAG synthase, and expression of human DIESL in Escherichia coli endows this organism with the ability to synthesize TAG. Although both DIESL and the DGATs function as diacylglycerol acyltransferases, they contribute to the cellular TAG pool under specific conditions. Functionally, DIESL synthesizes TAG at the expense of membrane phospholipids and maintains mitochondrial function during periods of extracellular lipid starvation. In mice, DIESL deficiency impedes rapid postnatal growth and affects energy homeostasis during changes in nutrient availability. We have therefore identified an alternative TAG biosynthetic pathway driven by DIESL under potent control by TMX1. << Less
Nature 0:0-0(2023) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.