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- Name help_outline N-acetyltaurine Identifier CHEBI:133737 Charge -1 Formula C4H8NO4S InChIKeyhelp_outline CXJAAWRLVGAKDV-UHFFFAOYSA-M SMILEShelp_outline C(CS([O-])(=O)=O)NC(C)=O 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,485 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline taurine Identifier CHEBI:507393 Charge 0 Formula C2H7NO3S InChIKeyhelp_outline XOAAWQZATWQOTB-UHFFFAOYSA-N SMILEShelp_outline [NH3+]CCS([O-])(=O)=O 2D coordinates Mol file for the small molecule Search links Involved in 46 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline acetate Identifier CHEBI:30089 (CAS: 71-50-1) help_outline Charge -1 Formula C2H3O2 InChIKeyhelp_outline QTBSBXVTEAMEQO-UHFFFAOYSA-M SMILEShelp_outline CC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 182 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:81107 | RHEA:81108 | RHEA:81109 | RHEA:81110 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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| Gene Ontology help_outline |
Publications
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PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity.
Wei W., Lyu X., Markhard A.L., Fu S., Mardjuki R.E., Cavanagh P.E., Zeng X., Rajniak J., Lu N., Xiao S., Zhao M., Moya-Garzon M.D., Truong S.D., Chou J.C., Wat L.W., Chidambaranathan-Reghupaty S., Coassolo L., Xu D., Shen F., Huang W., Ramirez C.B., Jang C., Li L., Svensson K.J., Fischbach M.A., Long J.Z.
Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans<sup>1-3</sup>. In endogenous taurine metabolism, dedicated enzymes are involved in the biosynthesis of taurine from cysteine and in the downstream metabolism of secondary taurine metabolites<sup>4 ... >> More
Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans<sup>1-3</sup>. In endogenous taurine metabolism, dedicated enzymes are involved in the biosynthesis of taurine from cysteine and in the downstream metabolism of secondary taurine metabolites<sup>4,5</sup>. One taurine metabolite is N-acetyltaurine<sup>6</sup>. Levels of N-acetyltaurine are dynamically regulated by stimuli that alter taurine or acetate flux, including endurance exercise<sup>7</sup>, dietary taurine supplementation<sup>8</sup> and alcohol consumption<sup>6,9</sup>. So far, the identities of the enzymes involved in N-acetyltaurine metabolism, and the potential functions of N-acetyltaurine itself, have remained unknown. Here we show that the body mass index associated orphan enzyme phosphotriesterase-related (PTER)<sup>10</sup> is a physiological N-acetyltaurine hydrolase. In vitro, PTER catalyses the hydrolysis of N-acetyltaurine to taurine and acetate. In mice, PTER is expressed in the kidney, liver and brainstem. Genetic ablation of Pter in mice results in complete loss of tissue N-acetyltaurine hydrolysis activity and a systemic increase in N-acetyltaurine levels. After stimuli that increase taurine levels, Pter knockout mice exhibit reduced food intake, resistance to diet-induced obesity and improved glucose homeostasis. Administration of N-acetyltaurine to obese wild-type mice also reduces food intake and body weight in a GFRAL-dependent manner. These data place PTER into a central enzymatic node of secondary taurine metabolism and uncover a role for PTER and N-acetyltaurine in body weight control and energy balance. << Less
Nature 0:0-0(2024) [PubMed] [EuropePMC]
This publication is cited by 5 other entries.