Reaction participants Show >> << Hide
- Name help_outline D-mannose 6-phosphate Identifier CHEBI:58735 (Beilstein: 4704942) help_outline Charge -2 Formula C6H11O9P InChIKeyhelp_outline NBSCHQHZLSJFNQ-QTVWNMPRSA-L SMILEShelp_outline OC1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 8 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 2-deoxy-4-epi-scyllo-inosose Identifier CHEBI:232323 Charge 0 Formula C6H10O5 InChIKeyhelp_outline GZYCZKBRQBKGJW-RARCZQNLSA-N SMILEShelp_outline [C@@H]1(O)[C@H](O)[C@H](O)[C@@H](O)C(=O)C1 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline phosphate Identifier CHEBI:43474 Charge -2 Formula HO4P InChIKeyhelp_outline NBIIXXVUZAFLBC-UHFFFAOYSA-L SMILEShelp_outline OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1,029 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:82407 | RHEA:82408 | RHEA:82409 | RHEA:82410 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
|
Publications
-
2-Deoxy-4-<i>epi</i>-<i>scyllo</i>-inosose (DEI) is the Product of EboD, a Highly Conserved Dehydroquinate Synthase-like Enzyme in Bacteria and Eustigmatophyte Algae.
Tanoeyadi S., Zhou W., Osborn A.R., Tsunoda T., Samadi A., Burade S., Waldo T.J., Higgins M.A., Mahmud T.
A cryptic cluster of genes, known as the ebo cluster, has been found in a variety of genomic contexts among bacteria and algae. In <i>Pseudomonas fluorescens</i> NZI7, the ebo cluster (a.k.a. EDB cluster) is involved in the bacterial repellent mechanism against nematode grazing. In cyanobacteria, ... >> More
A cryptic cluster of genes, known as the ebo cluster, has been found in a variety of genomic contexts among bacteria and algae. In <i>Pseudomonas fluorescens</i> NZI7, the ebo cluster (a.k.a. EDB cluster) is involved in the bacterial repellent mechanism against nematode grazing. In cyanobacteria, the cluster plays a role in the transport of the scytonemin monomer from the cytosol to the periplasm. Despite their broad distribution and interesting phenotypes, neither the pathway nor the functions of the enzymes are known. Here we show that EboD proteins from the ebo clusters in <i>Nostoc punctiforme</i> and <i>Sporocytophaga myxococcoides</i> catalyze the cyclization of mannose 6-phosphate to a novel cyclitol, 2-deoxy-4-<i>epi</i>-<i>scyllo</i>-inosose. The enzyme product is postulated to be a precursor of a signaling molecule or a transporter in the organisms. This study sheds the first light onto ebo/EDB pathways and established a functionally distinct enzyme that extends the diversity of sugar phosphate cyclases. << Less