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Results (16,970 reactions)

Reaction identifier Equation Enzyme class Enzymes
RHEA:23240 (6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + H+ + N-formyl-L-glutamate 5 protein(s) (UniProtKB)
RHEA:23244 propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine = H+ + norspermidine + S-methyl-5'-thioadenosine 3 protein(s) (UniProtKB)
RHEA:23248 myo-inositol + S-adenosyl-L-methionine = 1D-4-O-methyl-myo-inositol + H+ + S-adenosyl-L-homocysteine 1 protein(s) (UniProtKB)
RHEA:23252 [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate 79,126 protein(s) (UniProtKB)
RHEA:23256 adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H+ + 4 L-glutamate + 4 phosphate
  • EC:6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolyzing)
RHEA:23260 (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD+ = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H+ + NADH 1,861 protein(s) (UniProtKB)
RHEA:23264 (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADP+ = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H+ + NADPH
RHEA:23268 guanidinoacetate + H2O = glycine + urea
RHEA:23272 an N6-alkylaminopurine + UDP-α-D-glucose = an N6-alkylamino-7-β-D-glucosylpurine + H+ + UDP
RHEA:23276 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde
RHEA:23280 acetyl-CoA + cysteamine = CoA + S-acetylcysteamine
RHEA:23284 isopentenyl diphosphate = dimethylallyl diphosphate
  • EC:5.3.3.2 isopentenyl-diphosphate Delta-isomerase
18,387 protein(s) (UniProtKB)
RHEA:23288 acetaldehyde + CoA + NAD+ = acetyl-CoA + H+ + NADH 6,672 protein(s) (UniProtKB)
RHEA:23292 ATP + L-lombricine = ADP + H+ + N-phospho-L-lombricine 2 protein(s) (UniProtKB)
RHEA:23296 aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate 8,682 protein(s) (UniProtKB)
RHEA:23300 (2E)-geranyl diphosphate + isopentenyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate 466 protein(s) (UniProtKB)
RHEA:23304 atropine + H2O = H+ + tropate + tropine 1 protein(s) (UniProtKB)
RHEA:23308 (E)-sinapoyl-CoA + D-glucarate = 2-O-[(E)-sinapoyl]-D-glucarate + CoA
RHEA:23312 2 sucrose = 1F-β-D-fructosylsucrose + D-glucose 1 protein(s) (UniProtKB)
RHEA:23316 2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil
RHEA:23320 D-tryptophan + malonyl-CoA = CoA + H+ + N2-malonyl-D-tryptophan
RHEA:23324 2'-phospho-[ligated tRNA] + NAD+ = ADP-α-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide 3,923 protein(s) (UniProtKB)
RHEA:23328 a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal 946 protein(s) (UniProtKB)
RHEA:23332 (2R)-3-phosphoglycerate + GTP = (2R)-3-phospho-glyceroyl phosphate + GDP
RHEA:23336 2 H+ + H2O2 + 2 iodide = diiodine + 2 H2O 422 protein(s) (UniProtKB)
RHEA:23340 3-deoxy-α-D-manno-oct-2-ulosonate = D-arabinose + pyruvate
RHEA:23344 a purine D-ribonucleoside + H2O = a purine nucleobase + D-ribose 3 protein(s) (UniProtKB)
RHEA:23348 (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2 2 protein(s) (UniProtKB)
RHEA:23352 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde
  • EC:2.6.1.19 4-aminobutyrate--2-oxoglutarate transaminase
2,767 protein(s) (UniProtKB)
RHEA:23356 ATP + L-seryl-[rhodopsin] = ADP + H+ + O-phospho-L-seryl-[rhodopsin] 828 protein(s) (UniProtKB)
RHEA:23360 L-tyrosyl-[glycogenin] + UDP-α-D-glucose = α-D-glucosyl-L-tyrosyl-[glycogenin] + H+ + UDP 2,520 protein(s) (UniProtKB)
RHEA:23368 H+ + phenylglyoxylate = benzaldehyde + CO2 2 protein(s) (UniProtKB)
RHEA:23372 ATP + L-alanine + UDP-N-acetyl-α-D-muramate = ADP + H+ + phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanine
  • EC:6.3.2.8 UDP-N-acetylmuramate--L-alanine ligase
38,086 protein(s) (UniProtKB)
RHEA:23376 L-threonate + NAD+ = 3-dehydro-D-erythronate + H+ + NADH
RHEA:23380 an N-acetyl-α-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-α-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + H+ + UDP
  • EC:2.4.1.141 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
1,582 protein(s) (UniProtKB)
RHEA:23384 D-cellobiose = β-D-glucosyl-(1→4)-D-mannopyranose 1,883 protein(s) (UniProtKB)
RHEA:23388 ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + H+ 1 protein(s) (UniProtKB)
RHEA:23392 (n-1) H2O + RNA(n) = n a ribonucleoside 5'-phosphate + n H+
RHEA:23396 H2O + phloretin = 1,3,5-trihydroxybenzene + H+ + phloretate 2 protein(s) (UniProtKB)
RHEA:23400 7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H+
RHEA:23404 (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
  • EC:2.5.1.41 phosphoglycerol geranylgeranyltransferase
5,112 protein(s) (UniProtKB)
RHEA:23408 NADP+ + precorrin-6B = 2 H+ + NADPH + precorrin-6A 5 protein(s) (UniProtKB)
RHEA:23412 H2O + N-acetylputrescine = acetate + putrescine 8 protein(s) (UniProtKB)
RHEA:23416 (2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate 8,402 protein(s) (UniProtKB)
RHEA:23420 α,α-trehalose 6-phosphate + H2O = α,α-trehalose + phosphate 16,109 protein(s) (UniProtKB)
RHEA:23424 α-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate 29,575 protein(s) (UniProtKB)
RHEA:23428 3-O-(β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP-α-D-glucuronate = 3-O-(β-D-GlcA-(1→3)-β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + H+ + UDP
  • EC:2.4.1.226 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
12 protein(s) (UniProtKB)
RHEA:23432 (4S)-limonene + O2 + reduced [NADPH—hemoprotein reductase] = (4S)-perillyl alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase] 3 protein(s) (UniProtKB)
RHEA:23436 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate
6,683 protein(s) (UniProtKB)
RHEA:23440 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H+
RHEA:23444 (S)-lactate + NAD+ = H+ + NADH + pyruvate 18,675 protein(s) (UniProtKB)
RHEA:23448 3-deoxy-α-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-β-D-manno-octulosonate + diphosphate
  • EC:2.7.7.38 3-deoxy-manno-octulosonate cytidylyltransferase
18,530 protein(s) (UniProtKB)
RHEA:23452 2'-deoxyadenosine + ATP = ADP + dAMP + H+ 530 protein(s) (UniProtKB)
RHEA:23456 (9Z,12Z)-octadecadienoate + AH2 + O2 = A + crepenynate + 2 H2O
RHEA:23460 benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H+
RHEA:23464 3-O-(β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-α-D-galactosamine = 3-O-(β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + H+ + UDP
  • EC:2.4.1.174 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase
5 protein(s) (UniProtKB)
RHEA:23468 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4+ 2 protein(s) (UniProtKB)
RHEA:23472 2 α,α'-trehalose 6-mycolate = α,α'-trehalose 6,6'-bismycolate + α,α-trehalose 1,947 protein(s) (UniProtKB)
RHEA:23476 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+ = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O 42,083 protein(s) (UniProtKB)
RHEA:23480 2-methylene-3-methylsuccinate = dimethylmaleate 1 protein(s) (UniProtKB)
RHEA:23484 A + D-cellobiose = AH2 + D-cellobiono-1,5-lactone 1 protein(s) (UniProtKB)
RHEA:23488 1,4-benzoquinone + H+ + NADPH = hydroquinone + NADP+ 1 protein(s) (UniProtKB)
RHEA:23492 UDP-α-D-glucosamine = UDP-α-D-galactosamine
RHEA:23496 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate
RHEA:23500 H2O + N6-propanoyl-L-lysyl-[protein] + NAD+ = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
7 protein(s) (UniProtKB)
RHEA:23504 adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol + adenosylcob(III)yrate 2 protein(s) (UniProtKB)
RHEA:23508 (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate
  • EC:3.5.1.93 glutaryl-7-aminocephalosporanic-acid acylase
4 protein(s) (UniProtKB)
RHEA:23512 α,α-trehalose + phosphate = β-D-glucose 1-phosphate + D-glucose 2 protein(s) (UniProtKB)
RHEA:23516 (R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H+ 763 protein(s) (UniProtKB)
RHEA:23520 acetyl-CoA + propanoate = acetate + propanoyl-CoA 2 protein(s) (UniProtKB)
RHEA:23524 1-O-(trans-cinnamoyl)-β-D-glucose + an alcohol = an alkyl cinnamate + β-D-glucose
RHEA:23532 ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate 6 protein(s) (UniProtKB)
RHEA:23536 α-D-glucose 1-phosphate = α-D-glucose 6-phosphate
  • EC:5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
  • EC:5.4.2.5 phosphoglucomutase (glucose-cofactor)
14,417 protein(s) (UniProtKB)
RHEA:23540 ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu 51,142 protein(s) (UniProtKB)
RHEA:23544 a flavonol 3-O-β-D-glucosyl-(1→2)-β-D-glucoside + UDP-α-D-glucose = a flavonol 3-O-β-D-glucosyl-(1→2)-β-D-glucosyl-(1→2)-β-D-glucoside + H+ + UDP
RHEA:23548 guanosine966 in 16S rRNA + S-adenosyl-L-methionine = H+ + N2-methylguanosine966 in 16S rRNA + S-adenosyl-L-homocysteine
  • EC:2.1.1.171 16S rRNA (guanine(966)-N(2))-methyltransferase
6,202 protein(s) (UniProtKB)
RHEA:23552 2-methylpropane-1,2-diol + NAD+ = 2-hydroxy-2-methylpropanal + H+ + NADH 1 protein(s) (UniProtKB)
RHEA:23556 D-alanine + L-glutamine = γ-L-glutamyl-D-alanine + NH4+
RHEA:23560 adenosylcob(III)inamide-GDP + α-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H+
  • EC:2.7.8.26 adenosylcobinamide-GDP ribazoletransferase
21,569 protein(s) (UniProtKB)
RHEA:23564 2 columbamine + O2 = 2 berberine + 2 H2O
RHEA:23568 (2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]
  • EC:5.3.3.14 trans-2-decenoyl-[acyl-carrier-protein] isomerase
6,292 protein(s) (UniProtKB)
RHEA:23572 3-methylbutanoyl-CoA + 3 H+ + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisovalerophenone 3 protein(s) (UniProtKB)
RHEA:23576 (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH—hemoprotein reductase] = berbamunine + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase] 1 protein(s) (UniProtKB)
RHEA:23580 prostaglandin H2 = prostaglandin I2 819 protein(s) (UniProtKB)
RHEA:23584 7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H+ + phosphate 12,073 protein(s) (UniProtKB)
RHEA:23588 oxalate + succinyl-CoA = oxalyl-CoA + succinate
RHEA:23592 glycerol + NADP+ = D-glyceraldehyde + H+ + NADPH 248 protein(s) (UniProtKB)
RHEA:23596 H2O + 2 NAD+ + UDP-α-D-glucose = 3 H+ + 2 NADH + UDP-α-D-glucuronate 46,847 protein(s) (UniProtKB)
RHEA:23600 2-oxoglutarate + L-2-aminohexanoate = 2-oxohexanoate + L-glutamate
RHEA:23604 kievitone hydrate = H2O + kievitone 1 protein(s) (UniProtKB)
RHEA:23608 H+ + H2O + N-isopropylammelide = cyanurate + isopropylamine
  • EC:3.5.4.42 N-isopropylammelide isopropylaminohydrolase
1 protein(s) (UniProtKB)
RHEA:23612 1,2-dihydro-α-santonin + NAD+ = α-santonin + H+ + NADH
RHEA:23616 1,2-dihydro-α-santonin + NADP+ = α-santonin + H+ + NADPH
RHEA:23620 ATP + N2-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminate + diphosphate + H+
  • EC:6.3.3.4 (carboxyethyl)arginine beta-lactam-synthase
1 protein(s) (UniProtKB)
RHEA:23624 a 5,6-dihydrouridine in tRNA + NADP+ = a uridine in tRNA + H+ + NADPH
35,814 protein(s) (UniProtKB)
RHEA:23628 a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose = a β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl derivative + GDP + H+
  • EC:2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
489 protein(s) (UniProtKB)
RHEA:23632 D-threo-isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH 4,204 protein(s) (UniProtKB)
RHEA:23640 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate 1,149 protein(s) (UniProtKB)
RHEA:23644 lithocholate + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + hyodeoxycholate + oxidized [NADPH—hemoprotein reductase] 1 protein(s) (UniProtKB)
RHEA:23648 dTDP-6-deoxy-β-L-talose + NADP+ = dTDP-4-dehydro-β-L-rhamnose + H+ + NADPH 1 protein(s) (UniProtKB)