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Results (18,343 reactions)

Reaction identifier Equation Enzyme class Enzymes
RHEA:10000 pentanamide + H2O = pentanoate + NH4+
RHEA:10004 benzyl isothiocyanate = benzyl thiocyanate
RHEA:10008 a hydroperoxide + [protein]-dithiol = [protein]-disulfide + an alcohol + H2O
1,182 protein(s) (UniProtKB)
RHEA:10012 (R)-6-hydroxynicotine + O2 + H2O = 6-hydroxypseudooxynicotine + H2O2 1 protein(s) (UniProtKB)
RHEA:10016 O-sinapoylcholine + H2O = (E)-sinapate + choline + H+ 1 protein(s) (UniProtKB)
RHEA:10020 L-saccharopine + NADP+ + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H+
  • EC:1.5.1.10 saccharopine dehydrogenase (NADP(+), L-glutamate-forming)
1,170 protein(s) (UniProtKB)
RHEA:10024 L-lysyl-[histone] + S-adenosyl-L-methionine = N6-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H+
3,262 protein(s) (UniProtKB)
RHEA:10028 D-glutamate + O2 + H2O = 2-oxoglutarate + H2O2 + NH4+ 1,105 protein(s) (UniProtKB)
RHEA:10032 [protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4+
RHEA:10036 4-hydroxy-3-methoxy-benzenemethanol + O2 = vanillin + H2O2 1 protein(s) (UniProtKB)
RHEA:10040 adenosine 3',5'-bisphosphate + H2O = AMP + phosphate 16,830 protein(s) (UniProtKB)
RHEA:10044 cyclohexanol + NAD+ = cyclohexanone + NADH + H+ 4 protein(s) (UniProtKB)
RHEA:10048 O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H+
  • EC:2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
961 protein(s) (UniProtKB)
RHEA:10052 (2R)-hydroxy-4-methylpentanoate + NAD+ = 4-methyl-2-oxopentanoate + NADH + H+ 2 protein(s) (UniProtKB)
RHEA:10056 (3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4+ 2 protein(s) (UniProtKB)
RHEA:10060 D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H+
RHEA:10064 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = 2-methylserine + (6S)-5,6,7,8-tetrahydrofolate 2,567 protein(s) (UniProtKB)
RHEA:10068 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-α-D-glucose = 4-O-[(2-β-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP + n H+
  • EC:2.4.1.53 poly(ribitol-phosphate) beta-glucosyltransferase
1 protein(s) (UniProtKB)
RHEA:10072 N,N-dimethylglycine + S-adenosyl-L-methionine = glycine betaine + S-adenosyl-L-homocysteine + H+ 4 protein(s) (UniProtKB)
RHEA:10076 lactose + H2O = β-D-galactose + D-glucose 138 protein(s) (UniProtKB)
RHEA:10080 dihydrophloroglucinol + NADP+ = 1,3,5-trihydroxybenzene + NADPH 1 protein(s) (UniProtKB)
RHEA:10084 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H+ 8 protein(s) (UniProtKB)
RHEA:10088 sucrose + UDP-α-D-galactose = 6F-α-D-galactosylsucrose + UDP + H+
RHEA:10092 a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate 1 protein(s) (UniProtKB)
RHEA:10096 a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + S-methyl-5'-thioadenosine + holo-[ACP] + H+ 4,600 protein(s) (UniProtKB)
RHEA:10100 a sterol ester + H2O = a sterol + a fatty acid + H+ 1,352 protein(s) (UniProtKB)
RHEA:10104 gibberellin A20 + 2-oxoglutarate + O2 = gibberellin A1 + succinate + CO2 154 protein(s) (UniProtKB)
RHEA:10108 (7S)-salutaridinol + NADP+ = salutaridine + NADPH + H+ 2 protein(s) (UniProtKB)
RHEA:10112 L-homocysteine + L-serine = L,L-cystathionine + H2O 8,399 protein(s) (UniProtKB)
RHEA:10116 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH
  • EC:1.1.1.44 phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)
  • EC:1.1.1.351 phosphogluconate dehydrogenase [NAD(P)(+)-dependent, decarboxylating]
21,871 protein(s) (UniProtKB)
RHEA:10120 adenosine in double-stranded RNA + H2O + H+ = inosine in double-stranded RNA + NH4+ 375 protein(s) (UniProtKB)
RHEA:10124 phenylacetone + NADPH + O2 + H+ = benzyl acetate + NADP+ + H2O 1 protein(s) (UniProtKB)
RHEA:10128 all-trans-violaxanthin = all-trans-neoxanthin 2 protein(s) (UniProtKB)
RHEA:10132 benzoate + ATP + CoA = benzoyl-CoA + AMP + diphosphate 11 protein(s) (UniProtKB)
RHEA:10136 2 glyoxylate + H+ = 2-hydroxy-3-oxopropanoate + CO2 588 protein(s) (UniProtKB)
RHEA:10140 prostaglandin F2α + NADP+ = prostaglandin D2 + NADPH + H+ 3 protein(s) (UniProtKB)
RHEA:10144 a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate 8,245 protein(s) (UniProtKB)
RHEA:10148 blasticidin S + H2O + H+ = deaminohydroxyblasticidin S + NH4+ 4 protein(s) (UniProtKB)
RHEA:10152 hydrogencarbonate + NH4+ + ATP = carbamoyl phosphate + ADP + H2O + H+ 3,960 protein(s) (UniProtKB)
RHEA:10156 dihydrochelirubine + reduced [NADPH—hemoprotein reductase] + O2 = 12-hydroxydihydrochelirubine + oxidized [NADPH—hemoprotein reductase] + H2O + H+
RHEA:10160 L-iditol + NAD+ = keto-L-sorbose + NADH + H+ 309 protein(s) (UniProtKB)
RHEA:10164 (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O 32,564 protein(s) (UniProtKB)
RHEA:10168 15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXα + reduced 2[4Fe-4S]-[ferredoxin] + 2 H+
  • EC:1.3.7.2 15,16-dihydrobiliverdin:ferredoxin oxidoreductase
44 protein(s) (UniProtKB)
RHEA:10172 (3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H+ 346 protein(s) (UniProtKB)
RHEA:10176 (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+ = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+ 1 protein(s) (UniProtKB)
RHEA:10180 (6R)-10-formyltetrahydrofolate + NADP+ + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H+ 2,463 protein(s) (UniProtKB)
RHEA:10184 (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H+ 2 protein(s) (UniProtKB)
RHEA:10188 acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+ 6,301 protein(s) (UniProtKB)
RHEA:10192 sulfate(out) + ATP + H2O = sulfate(in) + ADP + phosphate + H+ 68 protein(s) (UniProtKB)
RHEA:10196 (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O 7,205 protein(s) (UniProtKB)
RHEA:10200 butanoate + NAD+ = (2E)-2-butenoate + NADH + H+ 2 protein(s) (UniProtKB)
RHEA:10204 dimethylamine + oxidized [electron-transfer flavoprotein] + H2O + H+ = methylamine + reduced [electron-transfer flavoprotein] + formaldehyde 1 protein(s) (UniProtKB)
RHEA:10208 an N-terminal L-α-aminoacyl-[protein] + L-arginyl-tRNAArg = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNAArg + H+ 3,513 protein(s) (UniProtKB)
RHEA:10212 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate 311 protein(s) (UniProtKB)
RHEA:10216 [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H+ 21,668 protein(s) (UniProtKB)
RHEA:10220 tRNATyr + L-tyrosine + ATP = L-tyrosyl-tRNATyr + AMP + diphosphate + H+ 38,913 protein(s) (UniProtKB)
RHEA:10224 pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H+ 8,837 protein(s) (UniProtKB)
RHEA:10228 citrate = cis-aconitate + H2O
2 protein(s) (UniProtKB)
RHEA:10232 5,6-dihydrouridine 5'-phosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-α-D-ribose 1-diphosphate
  • EC:2.4.2.20 dioxotetrahydropyrimidine phosphoribosyltransferase
RHEA:10236 trans-2-coumarate + UDP-α-D-glucose = trans-β-D-glucosyl-2-hydroxycinnamate + UDP + H+
RHEA:10240 a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + NADH + H+
  • EC:1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
25,572 protein(s) (UniProtKB)
RHEA:10244 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+ 6,057 protein(s) (UniProtKB)
RHEA:10248 dUTP + H2O = dUMP + diphosphate + H+ 27,327 protein(s) (UniProtKB)
RHEA:10252 O-phospho-L-serine + hydrogen sulfide + H+ = L-cysteine + phosphate 2 protein(s) (UniProtKB)
RHEA:10256 [(1→4)-6-phospho-α-D-glucosyl](n) + n ATP + n H2O = [(1→4)-3,6-bisphospho-α-D-glucosyl](n) + n AMP + n phosphate + 2n H+ 2 protein(s) (UniProtKB)
RHEA:10260 Mg2+(out) + ATP + H2O = Mg2+(in) + ADP + phosphate + H+ 8,335 protein(s) (UniProtKB)
RHEA:10264 α-D-glucose = β-D-glucose 18,504 protein(s) (UniProtKB)
RHEA:10268 2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate 940 protein(s) (UniProtKB)
RHEA:10272 a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+ 33,274 protein(s) (UniProtKB)
RHEA:10276 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H+ = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
  • EC:2.7.4.24 diphosphoinositol-pentakisphosphate 1-kinase
11,825 protein(s) (UniProtKB)
RHEA:10280 1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + S-adenosyl-L-homocysteine + H+ 8 protein(s) (UniProtKB)
RHEA:10284 L-leucine = (3R)-β-leucine
RHEA:10288 L-rhamnono-1,4-lactone + H2O = L-rhamnonate + H+ 1 protein(s) (UniProtKB)
RHEA:10292 D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+
  • EC:2.3.1.4 glucosamine-phosphate N-acetyltransferase
4,944 protein(s) (UniProtKB)
RHEA:10296 D-glyceraldehyde 3-phosphate + phosphate + NADP+ = (2R)-3-phospho-glyceroyl phosphate + NADPH + H+
  • EC:1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)
  • EC:1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)
3,772 protein(s) (UniProtKB)
RHEA:10300 D-glyceraldehyde 3-phosphate + phosphate + NAD+ = (2R)-3-phospho-glyceroyl phosphate + NADH + H+
  • EC:1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
  • EC:1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)
27,011 protein(s) (UniProtKB)
RHEA:10304 a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]
  • EC:2.3.1.40 acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase
1,315 protein(s) (UniProtKB)
RHEA:10312 terephthalate + NADH + O2 + H+ = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ 10 protein(s) (UniProtKB)
RHEA:10316 thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2 102 protein(s) (UniProtKB)
RHEA:10320 trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O 1,951 protein(s) (UniProtKB)
RHEA:10324 an L-glycol + NADP+ = a 2-hydroxycarbonyl + NADPH + H+
RHEA:10328 an L-glycol + NAD+ = a 2-hydroxycarbonyl + NADH + H+
RHEA:10332 a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  • EC:2.3.1.62 2-acylglycerophosphocholine O-acyltransferase
2 protein(s) (UniProtKB)
RHEA:10336 citrate = D-threo-isocitrate 44,555 protein(s) (UniProtKB)
RHEA:10340 (2E,6E)-farnesyl diphosphate = (−)-vetispiradiene + diphosphate 30 protein(s) (UniProtKB)
RHEA:10344 a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA 333 protein(s) (UniProtKB)
RHEA:10348 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + phosphate + H+ 11,907 protein(s) (UniProtKB)
RHEA:10352 an N-acetylarylalkylamine + H2O = an aralkylamine + acetate 1 protein(s) (UniProtKB)
RHEA:10356 3α-hydroxy-5β-androstan-17-one + NAD+ = 5β-androstane-3,17-dione + NADH + H+
  • EC:1.1.1.152 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase
RHEA:10360 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H+ 1 protein(s) (UniProtKB)
RHEA:10364 dodecanoyl-CoA + 2-oxoglutarate + H2O = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H+
RHEA:10368 dTDP-4-amino-4,6-dideoxy-α-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-α-D-glucose + L-glutamate
  • EC:2.6.1.59 dTDP-4-amino-4,6-dideoxygalactose transaminase
1,258 protein(s) (UniProtKB)
RHEA:10372 phenylglyoxylate + NAD+ + CoA = benzoyl-CoA + CO2 + NADH
  • EC:1.2.1.58 phenylglyoxylate dehydrogenase (acylating)
5 protein(s) (UniProtKB)
RHEA:10376 Cu2+(in) + ATP + H2O = Cu2+(out) + ADP + phosphate + H+ 2,939 protein(s) (UniProtKB)
RHEA:10380 orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-α-D-ribose 1-diphosphate 27,668 protein(s) (UniProtKB)
RHEA:10384 cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate = β-cyclopiazonate + diphosphate
1 protein(s) (UniProtKB)
RHEA:10388 oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2 9,273 protein(s) (UniProtKB)
RHEA:10392 (E)-cinnamyl alcohol + NADP+ = (E)-cinnamaldehyde + NADPH + H+ 2,069 protein(s) (UniProtKB)
RHEA:10396 an L-α-amino acid + NAD+ + H2O = a 2-oxocarboxylate + NH4+ + NADH + H+
RHEA:10400 L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine