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Results (15,453 reactions)

Reaction identifier Equation Enzyme class Enzymes
RHEA:10000 H2O + pentanamide = NH4+ + pentanoate
RHEA:10004 benzyl isothiocyanate = benzyl thiocyanate
RHEA:10008 [protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O
8 protein(s) (UniProtKB)
RHEA:10012 (R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2 1 protein(s) (UniProtKB)
RHEA:10016 H2O + O-sinapoylcholine = (E)-sinapate + choline + H+ 1 protein(s) (UniProtKB)
RHEA:10020 H2O + L-saccharopine + NADP+ = (S)-2-amino-6-oxohexanoate + H+ + L-glutamate + NADPH
  • EC:1.5.1.10 saccharopine dehydrogenase (NADP(+), L-glutamate-forming)
4 protein(s) (UniProtKB)
RHEA:10024 L-lysyl-[histone] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
1,635 protein(s) (UniProtKB)
RHEA:10028 D-glutamate + H2O + O2 = 2-oxoglutarate + H2O2 + NH4+
RHEA:10032 [protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4+
RHEA:10036 4-hydroxy-3-methoxy-benzenemethanol + O2 = H2O2 + vanillin 1 protein(s) (UniProtKB)
RHEA:10040 adenosine 3',5'-bisphosphate + H2O = AMP + phosphate 14,522 protein(s) (UniProtKB)
RHEA:10044 cyclohexanol + NAD+ = cyclohexanone + H+ + NADH 4 protein(s) (UniProtKB)
RHEA:10048 methanethiol + O-acetyl-L-homoserine = acetate + H+ + L-methionine
  • EC:2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
5 protein(s) (UniProtKB)
RHEA:10052 (R)-2-hydroxy-4-methylpentanoate + NAD+ = 4-methyl-2-oxopentanoate + H+ + NADH
RHEA:10056 (3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4+ 2 protein(s) (UniProtKB)
RHEA:10060 acetyl-CoA + D-tryptophan = CoA + H+ + N-acetyl-D-tryptophan
RHEA:10064 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine 219 protein(s) (UniProtKB)
RHEA:10068 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-α-D-glucose = 4-O-[(2-β-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H+ + n UDP
  • EC:2.4.1.53 poly(ribitol-phosphate) beta-glucosyltransferase
1 protein(s) (UniProtKB)
RHEA:10072 N,N-dimethylglycine + S-adenosyl-L-methionine = glycine betaine + H+ + S-adenosyl-L-homocysteine 1 protein(s) (UniProtKB)
RHEA:10076 H2O + lactose = β-D-galactose + D-glucose 4 protein(s) (UniProtKB)
RHEA:10080 dihydrophloroglucinol + NADP+ = 1,3,5-trihydroxybenzene + NADPH 1 protein(s) (UniProtKB)
RHEA:10084 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H+ 8 protein(s) (UniProtKB)
RHEA:10088 sucrose + UDP-α-D-galactose = 6F-α-D-galactosylsucrose + H+ + UDP
RHEA:10092 a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate 1 protein(s) (UniProtKB)
RHEA:10096 a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H+ + holo-[ACP] + S-methyl-5'-thioadenosine 6,257 protein(s) (UniProtKB)
RHEA:10100 a sterol ester + H2O = a fatty acid + a sterol + H+ 12 protein(s) (UniProtKB)
RHEA:10104 2-oxoglutarate + gibberellin A20 + O2 = CO2 + gibberellin A1 + succinate 10 protein(s) (UniProtKB)
RHEA:10108 (7S)-salutaridinol + NADP+ = H+ + NADPH + salutaridine 2 protein(s) (UniProtKB)
RHEA:10112 L-homocysteine + L-serine = H2O + L,L-cystathionine 7,537 protein(s) (UniProtKB)
RHEA:10116 6-phospho-D-gluconate + NADP+ = CO2 + D-ribulose 5-phosphate + NADPH
  • EC:1.1.1.44 phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)
  • EC:1.1.1.351 phosphogluconate dehydrogenase [NAD(P)(+)-dependent, decarboxylating]
23,790 protein(s) (UniProtKB)
RHEA:10120 adenosine in double-stranded RNA + H+ + H2O = inosine in double-stranded RNA + NH4+ 7 protein(s) (UniProtKB)
RHEA:10124 H+ + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP+ 1 protein(s) (UniProtKB)
RHEA:10128 all-trans-violaxanthin = all-trans-neoxanthin 2 protein(s) (UniProtKB)
RHEA:10132 ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate 11 protein(s) (UniProtKB)
RHEA:10136 2 glyoxylate + H+ = 2-hydroxy-3-oxopropanoate + CO2 2 protein(s) (UniProtKB)
RHEA:10140 NADP+ + prostaglandin F2α = H+ + NADPH + prostaglandin D2 4 protein(s) (UniProtKB)
RHEA:10144 a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate 10,239 protein(s) (UniProtKB)
RHEA:10148 blasticidin S + H+ + H2O = deaminohydroxyblasticidin S + NH4+ 4 protein(s) (UniProtKB)
RHEA:10152 ATP + hydrogencarbonate + NH4+ = ADP + carbamoyl phosphate + H+ + H2O 4,518 protein(s) (UniProtKB)
RHEA:10156 dihydrochelirubine + O2 + reduced [NADPH—hemoprotein reductase] = 12-hydroxydihydrochelirubine + H+ + H2O + oxidized [NADPH—hemoprotein reductase]
RHEA:10160 L-iditol + NAD+ = H+ + keto-L-sorbose + NADH 256 protein(s) (UniProtKB)
RHEA:10164 (2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate 43,356 protein(s) (UniProtKB)
RHEA:10168 15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXα + 2 H+ + reduced 2[4Fe-4S]-[ferredoxin]
  • EC:1.3.7.2 15,16-dihydrobiliverdin:ferredoxin oxidoreductase
119 protein(s) (UniProtKB)
RHEA:10172 (3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H+ 490 protein(s) (UniProtKB)
RHEA:10176 (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+ = (R)-3-(indol-3-yl)-2-oxobutanoate + H+ + NADH 1 protein(s) (UniProtKB)
RHEA:10180 (6S)-10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH 1,991 protein(s) (UniProtKB)
RHEA:10184 (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H+ 2 protein(s) (UniProtKB)
RHEA:10188 acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H+ 4,595 protein(s) (UniProtKB)
RHEA:10192 ATP + H2O + sulfate(out) = ADP + H+ + phosphate + sulfate(in) 68 protein(s) (UniProtKB)
RHEA:10196 (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O 12,224 protein(s) (UniProtKB)
RHEA:10200 butanoate + NAD+ = (2E)-2-butenoate + H+ + NADH 2 protein(s) (UniProtKB)
RHEA:10204 dimethylamine + H+ + H2O + oxidized [electron-transfer flavoprotein] = formaldehyde + methylamine + reduced [electron-transfer flavoprotein] 1 protein(s) (UniProtKB)
RHEA:10208 an N-terminal L-α-aminoacyl-[protein] + L-arginyl-tRNAArg = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNAArg 2,955 protein(s) (UniProtKB)
RHEA:10212 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate 3 protein(s) (UniProtKB)
RHEA:10216 [DNA-directed RNA polymerase] + ATP = ADP + H+ + phospho-[DNA-directed RNA polymerase] 2,300 protein(s) (UniProtKB)
RHEA:10220 ATP + L-tyrosine + tRNATyr = AMP + diphosphate + H+ + L-tyrosyl-tRNATyr 53,479 protein(s) (UniProtKB)
RHEA:10224 ATP + pyridoxal = ADP + H+ + pyridoxal 5'-phosphate 5,970 protein(s) (UniProtKB)
RHEA:10228 citrate = cis-aconitate + H2O
1 protein(s) (UniProtKB)
RHEA:10232 5,6-dihydrouridine 5'-monophosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-α-D-ribose 1-diphosphate
  • EC:2.4.2.20 dioxotetrahydropyrimidine phosphoribosyltransferase
RHEA:10236 trans-2-coumarate + UDP-α-D-glucose = H+ + trans-β-D-glucosyl-2-hydroxycinnamate + UDP
RHEA:10240 a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH
  • EC:1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
34,798 protein(s) (UniProtKB)
RHEA:10244 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+ 4,157 protein(s) (UniProtKB)
RHEA:10248 dUTP + H2O = diphosphate + dUMP + H+ 40,983 protein(s) (UniProtKB)
RHEA:10252 H+ + hydrogen sulfide + O-phospho-L-serine = L-cysteine + phosphate 2 protein(s) (UniProtKB)
RHEA:10256 [(1→4)-6-phospho-α-D-glucosyl](n) + n ATP + n H2O = [(1→4)-3,6-bisphospho-α-D-glucosyl](n) + n AMP + 2n H+ + n phosphate 2 protein(s) (UniProtKB)
RHEA:10260 ATP + H2O + Mg2+(out) = ADP + H+ + Mg2+(in) + phosphate 10,685 protein(s) (UniProtKB)
RHEA:10264 α-D-glucose = β-D-glucose 22,279 protein(s) (UniProtKB)
RHEA:10268 2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate 1,103 protein(s) (UniProtKB)
RHEA:10272 a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+ 32,435 protein(s) (UniProtKB)
RHEA:10276 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H+ = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
  • EC:2.7.4.24 diphosphoinositol-pentakisphosphate 1-kinase
8,989 protein(s) (UniProtKB)
RHEA:10280 1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + H+ + S-adenosyl-L-homocysteine 8 protein(s) (UniProtKB)
RHEA:10284 L-leucine = (3R)-β-leucine
RHEA:10288 H2O + L-rhamnono-1,4-lactone = H+ + L-rhamnonate 1 protein(s) (UniProtKB)
RHEA:10292 acetyl-CoA + D-glucosamine 6-phosphate = CoA + H+ + N-acetyl-D-glucosamine 6-phosphate
  • EC:2.3.1.4 glucosamine-phosphate N-acetyltransferase
5,552 protein(s) (UniProtKB)
RHEA:10296 D-glyceraldehyde 3-phosphate + NADP+ + phosphate = (2R)-3-phospho-glyceroyl phosphate + H+ + NADPH
  • EC:1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)
  • EC:1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)
3,027 protein(s) (UniProtKB)
RHEA:10300 D-glyceraldehyde 3-phosphate + NAD+ + phosphate = (2R)-3-phospho-glyceroyl phosphate + H+ + NADH
  • EC:1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
  • EC:1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)
19,682 protein(s) (UniProtKB)
RHEA:10304 a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]
  • EC:2.3.1.40 acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase
1,471 protein(s) (UniProtKB)
RHEA:10312 H+ + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ 6 protein(s) (UniProtKB)
RHEA:10316 2-oxoglutarate + O2 + thymine = 5-hydroxymethyluracil + CO2 + succinate 98 protein(s) (UniProtKB)
RHEA:10320 trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O 823 protein(s) (UniProtKB)
RHEA:10324 an L-glycol + NADP+ = a 2-hydroxycarbonyl + H+ + NADPH
RHEA:10328 an L-glycol + NAD+ = a 2-hydroxycarbonyl + H+ + NADH
RHEA:10332 a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  • EC:2.3.1.62 2-acylglycerophosphocholine O-acyltransferase
RHEA:10336 citrate = D-threo-isocitrate 50,261 protein(s) (UniProtKB)
RHEA:10340 (2E,6E)-farnesyl diphosphate = (−)-vetispiradiene + diphosphate 4 protein(s) (UniProtKB)
RHEA:10344 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA 8 protein(s) (UniProtKB)
RHEA:10348 5-oxo-L-proline + ATP + 2 H2O = ADP + H+ + L-glutamate + phosphate 14,714 protein(s) (UniProtKB)
RHEA:10352 an N-acetylarylalkylamine + H2O = acetate + an aralkylamine 1 protein(s) (UniProtKB)
RHEA:10356 3α-hydroxy-5β-androstan-17-one + NAD+ = 5β-androstane-3,17-dione + H+ + NADH
  • EC:1.1.1.152 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase
RHEA:10360 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H+ 1 protein(s) (UniProtKB)
RHEA:10364 2-oxoglutarate + dodecanoyl-CoA + H2O = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H+
RHEA:10368 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-α-D-galactose = dTDP-4-dehydro-6-deoxy-α-D-glucose + L-glutamate
  • EC:2.6.1.59 dTDP-4-amino-4,6-dideoxygalactose transaminase
1,433 protein(s) (UniProtKB)
RHEA:10372 CoA + NAD+ + phenylglyoxylate = benzoyl-CoA + CO2 + NADH
  • EC:1.2.1.58 phenylglyoxylate dehydrogenase (acylating)
5 protein(s) (UniProtKB)
RHEA:10376 ATP + Cu2+(in) + H2O = ADP + Cu2+(out) + H+ + phosphate 12 protein(s) (UniProtKB)
RHEA:10380 diphosphate + orotidine 5'-phosphate = 5-phospho-α-D-ribose 1-diphosphate + orotate 40,423 protein(s) (UniProtKB)
RHEA:10384 cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate = β-cyclopiazonate + diphosphate
1 protein(s) (UniProtKB)
RHEA:10388 GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate 10,321 protein(s) (UniProtKB)
RHEA:10392 (E)-cinnamyl alcohol + NADP+ = (E)-cinnamaldehyde + H+ + NADPH 166 protein(s) (UniProtKB)
RHEA:10396 an L-α-amino acid + H2O + NAD+ = a 2-oxocarboxylate + H+ + NADH + NH4+
RHEA:10400 L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine