Results (16,270 reactions)

Reaction identifier Equation Enzyme class Enzymes
RHEA:22512 3 H+ + precorrin-8X = hydrogenobyrinate 5 protein(s) (UniProtKB)
RHEA:22516 ATP + taurocyamine = ADP + H+ + N-phosphotaurocyamine 2 protein(s) (UniProtKB)
RHEA:22520 all-trans-retinal + H2O + O2 = all-trans-retinoate + H+ + H2O2 2 protein(s) (UniProtKB)
RHEA:22524 2 A + a carotenoid β-end derivative = a carotenoid φ-end derivative + 2 AH2 2 protein(s) (UniProtKB)
RHEA:22528 a flavonol 3-O-β-D-glucoside + UDP-β-L-rhamnose = a flavonol 3-O-[α-L-rhamnosyl-(1→6)-β-D-glucoside] + H+ + UDP
  • EC:2.4.1.159 flavonol-3-O-glucoside L-rhamnosyltransferase
1 protein(s) (UniProtKB)
RHEA:22532 (2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA
1 protein(s) (UniProtKB)
RHEA:22536 (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = (S)-tetrahydropalmatine + H+ + S-adenosyl-L-homocysteine
  • EC:2.1.1.89 tetrahydrocolumbamine 2-O-methyltransferase
2 protein(s) (UniProtKB)
RHEA:22540 5'-dehydroadenosine + H2O + O2 = 9-riburonosyladenine + H+ + H2O2
RHEA:22544 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine 1,895 protein(s) (UniProtKB)
RHEA:22548 H2O + L-lysine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + NH4+ 1 protein(s) (UniProtKB)
RHEA:22552 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H+ 14 protein(s) (UniProtKB)
RHEA:22560 (3R)-vestitone + NADP+ = 2'-hydroxyformononetin + 2 H+ + NADPH 4 protein(s) (UniProtKB)
RHEA:22564 a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + H+ + NADPH
  • EC:1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
  • EC:1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
  • EC:1.3.1.104 enoyl-[acyl-carrier-protein] reductase
7,351 protein(s) (UniProtKB)
RHEA:22568 ascopyrone M = ascopyrone P
RHEA:22572 A + H2O + N-methyl-L-glutamate = AH2 + formaldehyde + L-glutamate
RHEA:22576 an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H+
  • EC:3.1.1.81 quorum-quenching N-acyl-homoserine lactonase
3,163 protein(s) (UniProtKB)
RHEA:22580 (S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O 389 protein(s) (UniProtKB)
RHEA:22584 2 H+ + heme b = Fe2+ + protoporphyrin IX 33,072 protein(s) (UniProtKB)
RHEA:22588 4-aminobutanal = 1-pyrroline + H2O
RHEA:22592 (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (9S,13S,15Z)-12-oxophyto-10-15-dienoate 942 protein(s) (UniProtKB)
RHEA:22596 cephalosporin C + H2O = acetate + deacetylcephalosporin C + H+ 2 protein(s) (UniProtKB)
RHEA:22600 H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate 1,074 protein(s) (UniProtKB)
RHEA:22604 D-mannose = D-fructose 6 protein(s) (UniProtKB)
RHEA:22608 H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate 21,098 protein(s) (UniProtKB)
RHEA:22612 (3S)-citramalyl-CoA = acetyl-CoA + pyruvate 6 protein(s) (UniProtKB)
RHEA:22616 2 H+ + O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O
  • EC:1.21.3.5 sulochrin oxidase [(-)-bisdechlorogeodin-forming]
RHEA:22620 H+ + L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH4+
RHEA:22624 (S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate 6,864 protein(s) (UniProtKB)
RHEA:22628 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate
  • EC:6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
44,141 protein(s) (UniProtKB)
RHEA:22636 dCTP + H2O = dCMP + diphosphate + H+ 2,014 protein(s) (UniProtKB)
RHEA:22640 NADP+ + sphinganine = 3-oxosphinganine + H+ + NADPH 1,561 protein(s) (UniProtKB)
RHEA:22644 O2 + protopine + reduced [NADPH—hemoprotein reductase] = 6-hydroxyprotopine + H+ + H2O + oxidized [NADPH—hemoprotein reductase] 2 protein(s) (UniProtKB)
RHEA:22648 holo-[cytochrome c] = apo-[cytochrome c] + heme b 5,116 protein(s) (UniProtKB)
RHEA:22652 2-O-(α-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(α-D-glucopyranosyl)glycerol + phosphate 1 protein(s) (UniProtKB)
RHEA:22656 CDP-ethanolamine + L-serine = CMP + H+ + L-serine-phosphoethanolamine
RHEA:22660 a fatty acid + ATP + holo-[ACP] = a fatty acyl-[ACP] + AMP + diphosphate
RHEA:22664 2 1-O-(trans-sinapoyl)-β-D-glucose = 1,2-di-O-sinapoyl β-D-glucose + D-glucose
  • EC:2.3.1.103 sinapoylglucose--sinapoylglucose O-sinapoyltransferase
3 protein(s) (UniProtKB)
RHEA:22668 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine = H+ + lipid A disaccharide (E. coli) + UDP 1,402 protein(s) (UniProtKB)
RHEA:22672 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate 1,216 protein(s) (UniProtKB)
RHEA:22676 chlorophyllide a + H+ + NADPH + O2 = 71-hydroxychlorophyllide a + H2O + NADP+
RHEA:22680 dCTP + H+ + H2O = dUTP + NH4+ 12,480 protein(s) (UniProtKB)
RHEA:22684 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O
  • EC:1.14.99.65 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase
1 protein(s) (UniProtKB)
RHEA:22688 D-alanine + H2O + O2 = H2O2 + NH4+ + pyruvate 3 protein(s) (UniProtKB)
RHEA:22692 3-hydroxybenzoate + H+ + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD+ 5 protein(s) (UniProtKB)
RHEA:22696 AH2 + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone
RHEA:22700 gibberellin A12 aldehyde + O2 + reduced [NADPH—hemoprotein reductase] = gibberellin A12 + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase]
RHEA:22704 2 H2O + ricinine = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4+
RHEA:22708 H2O + S-acylglutathione = a carboxylate + glutathione + H+
RHEA:22712 adenosylcob(III)inamide phosphate + GTP + H+ = adenosylcob(III)inamide-GDP + diphosphate
  • EC:2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase
20,704 protein(s) (UniProtKB)
RHEA:22716 cholesterol + O2 + reduced [NADPH—hemoprotein reductase] = (24S)-hydroxycholesterol + H+ + H2O + oxidized [NADPH—hemoprotein reductase] 2 protein(s) (UniProtKB)
RHEA:22720 ATP + L-histidyl-[protein] = ADP + H+ + Nπ-phospho-L-histidyl-[protein]
RHEA:22724 a sterol + UDP-α-D-glucose = a sterol 3-β-D-glucoside + H+ + UDP 1,300 protein(s) (UniProtKB)
RHEA:22728 H+ + L-seryl-tRNASec + selenophosphate = L-selenocysteinyl-tRNASec + phosphate
  • EC:2.9.1.1 L-seryl-tRNA(Sec) selenium transferase
12,357 protein(s) (UniProtKB)
RHEA:22732 4-hydroxyphenylacetate + H+ = 4-methylphenol + CO2 105 protein(s) (UniProtKB)
RHEA:22736 5-formimidoyltetrahydrofolate + 2 H+ = (6R)-5,10-methenyltetrahydrofolate + NH4+
  • EC:4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase
6 protein(s) (UniProtKB)
RHEA:22740 ATP + D-hexose = ADP + D-hexose 6-phosphate + H+ 9,016 protein(s) (UniProtKB)
RHEA:22744 a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(N6,2'-O-dimethyladenosine) in mRNA + H+ + S-adenosyl-L-homocysteine
  • EC:2.1.1.62 mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
3 protein(s) (UniProtKB)
RHEA:22748 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
  • EC:4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
25,820 protein(s) (UniProtKB)
RHEA:22752 A + H2O + uracil = AH2 + barbiturate + H+
RHEA:22756 a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2 2,886 protein(s) (UniProtKB)
RHEA:22760 Cypridina luciferin + O2 = CO2 + + oxidized Cypridina luciferin 1 protein(s) (UniProtKB)
RHEA:22764 a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate 3,432 protein(s) (UniProtKB)
RHEA:22768 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one
RHEA:22772 L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O 5,130 protein(s) (UniProtKB)
RHEA:22776 2 H+ + H2O2 + 2 Mn2+ = 2 H2O + 2 Mn3+ 11 protein(s) (UniProtKB)
RHEA:22780 (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate 215 protein(s) (UniProtKB)
RHEA:22784 (2R)-O-phospho-3-sulfolactate = H+ + phosphoenolpyruvate + sulfite 4 protein(s) (UniProtKB)
RHEA:22788 dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + H+ + L-methionine
  • EC:2.1.1.3 thetin--homocysteine S-methyltransferase
RHEA:22792 isonocardicin A = nocardicin A 1 protein(s) (UniProtKB)
RHEA:22796 ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate + H+
RHEA:22800 cycloeucalenol = obtusifoliol 1 protein(s) (UniProtKB)
RHEA:22804 (6S,9R)-vomifoliol + NAD+ = (6S)-6-hydroxy-3-oxo-α-ionone + H+ + NADH
RHEA:22808 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2
RHEA:22812 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methenyltetrahydrofolate + NADPH
  • EC:1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP(+))
46,360 protein(s) (UniProtKB)
RHEA:22816 α-D-xylose = α-D-xylulofuranose 17,664 protein(s) (UniProtKB)
RHEA:22820 3-O-[α-D-xylosyl-(1→3)-β-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-α-D-xylose = 3-O-[α-D-xylosyl-(1→3)-α-D-xylosyl-(1→3)-β-D-glucosyl]-L-seryl-[EGF-like domain protein] + H+ + UDP 2 protein(s) (UniProtKB)
RHEA:22824 2'-deoxyuridine + phosphate = 2-deoxy-α-D-ribose 1-phosphate + uracil 5,706 protein(s) (UniProtKB)
RHEA:22828 1-(5-phospho-β-D-ribosyl)-ATP + H2O = 1-(5-phospho-β-D-ribosyl)-5'-AMP + diphosphate + H+ 34,628 protein(s) (UniProtKB)
RHEA:22832 H2O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH4+ 1 protein(s) (UniProtKB)
RHEA:22836 a fatty acyl-[ACP] + H+ + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]
  • EC:2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
58,107 protein(s) (UniProtKB)
RHEA:22840 D-glutamine + H2O = D-glutamate + NH4+
RHEA:22844 (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH—hemoprotein reductase] = glyceollin I + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase]
RHEA:22848 (3S)-hydroxyoctanedioyl-CoA + NAD+ = 3-oxooctanedioyl-CoA + H+ + NADH
1 protein(s) (UniProtKB)
RHEA:22852 L-serine + pyruvate = 3-hydroxypyruvate + L-alanine 1,041 protein(s) (UniProtKB)
RHEA:22856 (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA 1 protein(s) (UniProtKB)
RHEA:22860 ATP + H+ + nicotinate β-D-ribonucleotide = deamido-NAD+ + diphosphate
  • EC:2.7.7.18 nicotinate-nucleotide adenylyltransferase
45,961 protein(s) (UniProtKB)
RHEA:22864 L-lysine = D-lysine 659 protein(s) (UniProtKB)
RHEA:22868 3-chloro-L-alanine + thioglycolate = chloride + H+ + S-carboxymethyl-L-cysteine 1 protein(s) (UniProtKB)
RHEA:22872 2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen] 672 protein(s) (UniProtKB)
RHEA:22876 (R)-mandelamide + H2O = (R)-mandelate + NH4+ 1 protein(s) (UniProtKB)
RHEA:22880 2-oxoglutarate + L-arogenate = L-glutamate + prephenate 235 protein(s) (UniProtKB)
RHEA:22884 glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine 4 protein(s) (UniProtKB)
RHEA:22888 (R)-methylmalonyl-CoA = succinyl-CoA 3,837 protein(s) (UniProtKB)
RHEA:22892 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD+ = (6R)-5,10-methenyltetrahydrofolate + NADH
  • EC:1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD(+))
12 protein(s) (UniProtKB)
RHEA:22896 acetyl-CoA + 2n H+ + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP+ 3,639 protein(s) (UniProtKB)
RHEA:22900 (R)-acetoin + NAD+ = diacetyl + H+ + NADH 1 protein(s) (UniProtKB)
RHEA:22904 ent-7α-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH—hemoprotein reductase] = gibberellin A12 aldehyde + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase]
RHEA:22908 3',5'-cyclic AMP + H+ + H2O = 3',5'-cyclic IMP + NH4+ 1 protein(s) (UniProtKB)
RHEA:22912 L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine 2 protein(s) (UniProtKB)
RHEA:22916 4'-hydroxyacetophenone + H+ + NADPH + O2 = 4-acetoxyphenol + H2O + NADP+ 1 protein(s) (UniProtKB)