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Results (15,735 reactions)

Reaction identifier Equation Enzyme class Enzymes
RHEA:23884 nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine 4 protein(s) (UniProtKB)
RHEA:23888 [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H+ + phosphate 4,784 protein(s) (UniProtKB)
RHEA:23892 3-nitropropanoate + NADP+ = 3-nitroacrylate + H+ + NADPH
RHEA:23896 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate
  • EC:5.3.1.17 5-dehydro-4-deoxy-D-glucuronate isomerase
8,523 protein(s) (UniProtKB)
RHEA:23900 cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin 2,350 protein(s) (UniProtKB)
RHEA:23904 an α-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-α-aminoacyl-[peptide] 37,537 protein(s) (UniProtKB)
RHEA:23908 H+ + 2 methylcob(III)alamin-[methionine synthase] + NADP+ + 2 S-adenosyl-L-homocysteine = 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine 5 protein(s) (UniProtKB)
RHEA:23916 H+ + UDP-α-D-glucuronate = CO2 + UDP-α-D-xylose 865 protein(s) (UniProtKB)
RHEA:23920 (2S)-2-[5-amino-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide + fumarate 44,246 protein(s) (UniProtKB)
RHEA:23924 pppGp(2'-5')A = 2',3'-cGAMP + diphosphate
RHEA:23928 H2O + N8-acetylspermidine = acetate + spermidine 5 protein(s) (UniProtKB)
RHEA:23932 an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate
  • EC:5.1.3.9 N-acylglucosamine-6-phosphate 2-epimerase
8,430 protein(s) (UniProtKB)
RHEA:23936 D-gluconate + NADP+ = 5-dehydro-D-gluconate + H+ + NADPH 3 protein(s) (UniProtKB)
RHEA:23940 D-gluconate + NAD+ = 5-dehydro-D-gluconate + H+ + NADH 2 protein(s) (UniProtKB)
RHEA:23944 (E)-coniferol + UDP-α-D-glucose = 4-O-(β-D-glucosyl)-trans-coniferol + H+ + UDP 2 protein(s) (UniProtKB)
RHEA:23948 4-hydroxybutanoate + NAD+ = H+ + NADH + succinate semialdehyde 3 protein(s) (UniProtKB)
RHEA:23952 H2O + N-(2-phenylethyl)acetamide = 2-phenylethylamine + acetate
RHEA:23956 L-seryl-[protein] + UDP-N-acetyl-α-D-galactosamine = 3-O-[N-acetyl-α-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP
  • EC:2.4.1.41 polypeptide N-acetylgalactosaminyltransferase
66 protein(s) (UniProtKB)
RHEA:23960 H+ + 2 H2O2 + hexadecanoate = CO2 + 3 H2O + pentadecanal
RHEA:23964 (E)-coniferaldehyde + H2O + NADP+ = (E)-ferulate + 2 H+ + NADPH 3 protein(s) (UniProtKB)
RHEA:23968 (E)-coniferaldehyde + H2O + NAD+ = (E)-ferulate + 2 H+ + NADH 3 protein(s) (UniProtKB)
RHEA:23972 (2E)-glutaconyl-CoA + H+ + Na+(in) = (2E)-butenoyl-CoA + CO2 + Na+(out) 4 protein(s) (UniProtKB)
RHEA:23976 a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate
  • EC:6.5.1.4 RNA 3'-terminal-phosphate cyclase (ATP)
6,045 protein(s) (UniProtKB)
RHEA:23980 cyclomaltodextrin + H2O = linear maltodextrin 6 protein(s) (UniProtKB)
RHEA:23984 cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH 9 protein(s) (UniProtKB)
RHEA:23988 (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H+ + H2O + L-glutamate 6,221 protein(s) (UniProtKB)
RHEA:23992 1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA
  • EC:2.3.1.63 1-alkylglycerophosphocholine O-acyltransferase
RHEA:23996 a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H+ 16,793 protein(s) (UniProtKB)
RHEA:24000 a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]
  • EC:2.1.1.63 methylated-DNA--[protein]-cysteine S-methyltransferase
61,453 protein(s) (UniProtKB)
RHEA:24004 butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] 1,353 protein(s) (UniProtKB)
RHEA:24008 ATP + hypotaurocyamine = ADP + H+ + Nω-phosphohypotaurocyamine
RHEA:24012 γ-tocopherol + S-adenosyl-L-methionine = (+)-α-tocopherol + H+ + S-adenosyl-L-homocysteine 2 protein(s) (UniProtKB)
RHEA:24016 16-epivellosimine + acetyl-CoA = CoA + vinorine 1 protein(s) (UniProtKB)
RHEA:24020 2-(Nω-L-arginino)succinate = fumarate + L-arginine 43,199 protein(s) (UniProtKB)
RHEA:24024 (2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
RHEA:24028 2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate 1,270 protein(s) (UniProtKB)
RHEA:24032 sucrose = 6-O-α-D-glucopyranosyl-D-fructose
RHEA:24036 a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP 1 protein(s) (UniProtKB)
RHEA:24040 NADPH + 2 oxidized [cytochrome P450] = H+ + NADP+ + 2 reduced [cytochrome P450] 7,409 protein(s) (UniProtKB)
RHEA:24044 3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H+ 2 protein(s) (UniProtKB)
RHEA:24048 phosphate + sucrose = α-D-glucose 1-phosphate + D-fructose 1,027 protein(s) (UniProtKB)
RHEA:24052 a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]
  • EC:1.5.5.1 electron-transferring-flavoprotein dehydrogenase
19,685 protein(s) (UniProtKB)
RHEA:24056 a myo-inositol phosphate + H2O = myo-inositol + phosphate 39,910 protein(s) (UniProtKB)
RHEA:24060 N-hydroxy-L-tyrosine + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH—hemoprotein reductase]
RHEA:24064 2 5-aminolevulinate = H+ + 2 H2O + porphobilinogen 41,703 protein(s) (UniProtKB)
RHEA:24068 cyclohexanone + H+ + NADPH + O2 = H2O + hexano-6-lactone + NADP+ 1 protein(s) (UniProtKB)
RHEA:24072 (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O
RHEA:24076 a 3β-hydroxy-Δ5-steroid + NAD+ = a 3-oxo-Δ5-steroid + H+ + NADH 27 protein(s) (UniProtKB)
RHEA:24080 ATP + L-tryptophan + tRNATrp = AMP + diphosphate + H+ + L-tryptophanyl-tRNATrp 37,525 protein(s) (UniProtKB)
RHEA:24084 all-trans-zeaxanthin + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
1 protein(s) (UniProtKB)
RHEA:24092 2 H+ + O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O
  • EC:1.21.3.4 sulochrin oxidase [(+)-bisdechlorogeodin-forming]
RHEA:24096 isoorientin + S-adenosyl-L-methionine = H+ + isoscoparin + S-adenosyl-L-homocysteine
RHEA:24100 diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H+ 3 protein(s) (UniProtKB)
RHEA:24104 7-aminomethyl-7-carbaguanine + guanosine34 in tRNA = 7-aminomethyl-7-carbaguanosine34 in tRNA + guanine
  • EC:2.4.2.29 tRNA-guanosine(34) preQ1 transglycosylase
36,431 protein(s) (UniProtKB)
RHEA:24108 H2O + N-methyl-2-oxoglutaramate = 2-oxoglutarate + methylamine
RHEA:24112 2 glutathione + O2 = glutathione disulfide + H2O2
RHEA:24116 (2E)-geranyl diphosphate + H2O = (S)-linalool + diphosphate 8 protein(s) (UniProtKB)
RHEA:24120 H+ + leukotriene E4 + NADPH + O2 = 20-hydroxy-leukotriene E4 + H2O + NADP+
RHEA:24132 UDP-α-D-galactose = UDP-α-D-galactofuranose 7 protein(s) (UniProtKB)
RHEA:24136 3'-phosphoadenylyl sulfate + a primary amine = a sulfamate + adenosine 3',5'-bisphosphate + 2 H+ 2 protein(s) (UniProtKB)
RHEA:24140 guanosine2251 in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine2251 in 23S rRNA + H+ + S-adenosyl-L-homocysteine
  • EC:2.1.1.185 23S rRNA (guanosine(2251)-2'-O)-methyltransferase
8,008 protein(s) (UniProtKB)
RHEA:24144 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
RHEA:24148 D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2R)-3-phosphoglycerate + 3 H+ + 2 reduced [2Fe-2S]-[ferredoxin]
  • EC:1.2.7.6 glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
1 protein(s) (UniProtKB)
RHEA:24152 adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H+ 27,908 protein(s) (UniProtKB)
RHEA:24156 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP
RHEA:24160 D-galactose + O2 = D-galacto-hexodialdose + H2O2 2 protein(s) (UniProtKB)
RHEA:24164 [thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein] 53,720 protein(s) (UniProtKB)
RHEA:24168 3-O-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-seryl-[protein] + UDP-α-D-glucuronate = 3-O-(β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-seryl-[protein] + H+ + UDP
  • EC:2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
4,542 protein(s) (UniProtKB)
RHEA:24172 A + a 3-oxo-5β-steroid = a 3-oxo-Δ4-steroid + AH2
RHEA:24176 [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H+ + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] 14,939 protein(s) (UniProtKB)
RHEA:24180 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H+ + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein]
1,461 protein(s) (UniProtKB)
RHEA:24184 4,5-dihydroxyphthalate + H+ = 3,4-dihydroxybenzoate + CO2 2 protein(s) (UniProtKB)
RHEA:24188 cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + H+ + NADH
  • EC:1.3.1.60 dibenzothiophene dihydrodiol dehydrogenase
2 protein(s) (UniProtKB)
RHEA:24192 (2R,4S)-2,4-diaminopentanoate + H2O + NADP+ = (2R)-2-amino-4-oxopentanoate + H+ + NADPH + NH4+ 1 protein(s) (UniProtKB)
RHEA:24196 (2R,4S)-2,4-diaminopentanoate + H2O + NAD+ = (2R)-2-amino-4-oxopentanoate + H+ + NADH + NH4+ 2 protein(s) (UniProtKB)
RHEA:24200 4-aminobenzoate + H+ = aniline + CO2
RHEA:24204 acetyl phosphate + H+ + sulfite = phosphate + sulfoacetaldehyde 6 protein(s) (UniProtKB)
RHEA:24208 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH
  • EC:1.1.1.292 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)
2 protein(s) (UniProtKB)
RHEA:24212 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H+ 15,836 protein(s) (UniProtKB)
RHEA:24216 (2E,6E)-farnesal + H2O + NAD+ = (2E,6E)-farnesoate + 2 H+ + NADH 5 protein(s) (UniProtKB)
RHEA:24220 β-myrcene + O2 + reduced [NADPH—hemoprotein reductase] = (4R)-ipsdienol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]
RHEA:24224 (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP+ = 4-methylcatechol + CO2 + NADPH
  • EC:1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
RHEA:24228 (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD+ = 4-methylcatechol + CO2 + NADH
  • EC:1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
RHEA:24232 2-dehydro-3-deoxy-D-gluconate + NAD+ = 3-deoxy-D-glycero-2,5-hexodiulosonate + H+ + NADH
  • EC:1.1.1.127 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
5 protein(s) (UniProtKB)
RHEA:24236 2 Fe(III)-[cytochrome c] + H2O + trimethylamine = 2 Fe(II)-[cytochrome c] + 3 H+ + trimethylamine N-oxide 1,557 protein(s) (UniProtKB)
RHEA:24240 A + AMP + 2 H+ + sulfite = adenosine 5'-phosphosulfate + AH2 1 protein(s) (UniProtKB)
RHEA:24244 NADP+ + pseudotropine = H+ + NADPH + tropinone 3 protein(s) (UniProtKB)
RHEA:24248 glyoxylate + L-alanine = glycine + pyruvate 1,408 protein(s) (UniProtKB)
RHEA:24252 H2O + P1,P4-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H+
  • EC:3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
19,315 protein(s) (UniProtKB)
RHEA:24256 ATP + kanamycin A = ADP + H+ + kanamycin 3'-phosphate 1,898 protein(s) (UniProtKB)
RHEA:24260 (3E)-2-oxohex-3-enedioate + H+ = 2-oxopent-4-enoate + CO2 3 protein(s) (UniProtKB)
RHEA:24264 D-xylulose 5-phosphate + formaldehyde = D-glyceraldehyde 3-phosphate + dihydroxyacetone 2 protein(s) (UniProtKB)
RHEA:24268 2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ + NADPH
  • EC:1.3.1.40 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase
RHEA:24272 H+ + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = H2O + Mg-131-hydroxyprotoporphyrin 13-monomethyl ester + NADP+
RHEA:24276 acetate + diphosphate = acetyl phosphate + phosphate
RHEA:24284 L-aspartate 4-semialdehyde + NADP+ + phosphate = 4-phospho-L-aspartate + H+ + NADPH 41,028 protein(s) (UniProtKB)
RHEA:24288 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine
RHEA:24292 acetyl-CoA + L-glutamate = CoA + H+ + N-acetyl-L-glutamate 39,680 protein(s) (UniProtKB)
RHEA:24296 (S)-dihydroorotate + H2O = H+ + N-carbamoyl-L-aspartate 32,047 protein(s) (UniProtKB)
RHEA:24300 2 cob(I)yrinate a,c diamide + FMN + 3 H+ = 2 cob(II)yrinate a,c diamide + FMNH2